Chronic moderate hypercapnia suppresses ventilatory responses to acute CO<sub>2</sub> challenges.
Buchholz KJ, Neumueller SE, Burgraff NJ, Hodges MR, Pan L, Forster HV.
J Appl Physiol (1985). 2022 Nov 1;133(5):1106-1118. doi: 10.1152/japplphysiol.00407.2022. Epub 2022 Sep 22.
Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest.
Eastwood G, Nichol AD, Hodgson C, Parke RL, McGuinness S, Nielsen N, Bernard S, Skrifvars MB, Stub D, Taccone FS, Archer J, Kutsogiannis D, Dankiewicz J, Lilja G, Cronberg T, Kirkegaard H, Capellier G, Landoni G, Horn J, Olasveengen T, Arabi Y, Chia YW, Markota A, Hænggi M, Wise MP, Grejs AM, Christensen S, Munk-Andersen H, Granfeldt A, Andersen GØ, Qvigstad E, Flaa A, Thomas M, Sweet K, Bewley J, Bäcklund M, Tiainen M, Iten M, Levis A, Peck L, Walsham J, Deane A, Ghosh A, Annoni F, Chen Y, Knight D, Lesona E, Tlayjeh H, Svenšek F, McGuigan PJ, Cole J, Pogson D, Hilty MP, Düring JP, Bailey MJ, Paul E, Ady B, Ainscough K, Hunt A, Monahan S, Trapani T, Fahey C, Bellomo R; TAME Study Investigators.
N Engl J Med. 2023 Jul 6;389(1):45-57. doi: 10.1056/NEJMoa2214552. Epub 2023 Jun 15.
The haemodynamic effects of moderate hypercapnia: Important lessons from a sub-study of the TAME trial.
Skrifvars MB.
Resuscitation. 2023 Dec;193:110000. doi: 10.1016/j.resuscitation.2023.110000. Epub 2023 Oct 16.
Obstructive sleep apnoea syndrome.
Lévy P, Kohler M, McNicholas WT, Barbé F, McEvoy RD, Somers VK, Lavie L, Pépin JL.
Nat Rev Dis Primers. 2015 Jun 25;1:15015. doi: 10.1038/nrdp.2015.15.
Home High-Flow Nasal Cannula Oxygen Therapy for Stable Hypercapnic COPD: A Randomized Clinical Trial.
Nagata K, Horie T, Chohnabayashi N, Jinta T, Tsugitomi R, Shiraki A, Tokioka F, Kadowaki T, Watanabe A, Fukui M, Kitajima T, Sato S, Tsuda T, Kishimoto N, Kita H, Mori Y, Nakayama M, Takahashi K, Tsuboi T, Yoshida M, Hataji O, Fuke S, Kagajo M, Nishine H, Kobayashi H, Nakamura H, Okuda M, Tachibana S, Takata S, Osoreda H, Minami K, Nishimura T, Ishida T, Terada J, Takeuchi N, Kohashi Y, Inoue H, Nakagawa Y, Kikuchi T, Tomii K.
Am J Respir Crit Care Med. 2022 Dec 1;206(11):1326-1335. doi: 10.1164/rccm.202201-0199OC.
Profound hypercapnia but only moderate hypoxia found during underwater rugby play.
Lindholm P, Lund H, Blogg L, Gennser M.
Undersea Hyperb Med. 2022 Third Quarter;49(3):367-372. doi: 10.22462/05.06.2022.10.
Permissive hypercapnia.
Hickling KG.
Respir Care Clin N Am. 2002 Jun;8(2):155-69, v. doi: 10.1016/s1078-5337(02)00006-0.
Moderate hypercapnia may not contribute to postoperative delirium in patients undergoing bronchoscopic intervention.
Cheng Q, Li L, Yang M, Sun L, Li R, Huang R, Ma J.
Medicine (Baltimore). 2019 May;98(22):e15906. doi: 10.1097/MD.0000000000015906.
Mild and moderate chronic hypercapnia elicit distinct transcriptomic responses of immune function in cardiorespiratory nuclei.
Grams KJ, Neumueller SE, Mouradian GC Jr, Burgraff NJ, Hodges MR, Pan L, Forster HV.
Physiol Genomics. 2023 Nov 1;55(11):487-503. doi: 10.1152/physiolgenomics.00038.2023. Epub 2023 Aug 21.
High flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease with acute-moderate hypercapnic respiratory failure: an observational cohort study.
Sun J, Li Y, Ling B, Zhu Q, Hu Y, Tan D, Geng P, Xu J.
Int J Chron Obstruct Pulmon Dis. 2019 Jun 5;14:1229-1237. doi: 10.2147/COPD.S206567. eCollection 2019.
