Mechanical activation of lung epithelial cells through the ion channel Piezo1 activates the metalloproteinases ADAM10 and ADAM17 and promotes growth factor and adhesion molecule release.
Grannemann C, Pabst A, Honert A, Schieren J, Martin C, Hank S, Böll S, Bläsius K, Düsterhöft S, Jahr H, Merkel R, Leube R, Babendreyer A, Ludwig A.
Biomater Adv. 2023 Sep;152:213516. doi: 10.1016/j.bioadv.2023.213516. Epub 2023 Jun 12.
IL-4 and IL-13, not eosinophils, drive type 2 airway inflammation, remodeling and lung function decline.
Scott G, Asrat S, Allinne J, Keat Lim W, Nagashima K, Birchard D, Srivatsan S, Ajithdoss DK, Oyejide A, Ben LH, Walls J, Le Floc'h A, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM.
Cytokine. 2023 Feb;162:156091. doi: 10.1016/j.cyto.2022.156091. Epub 2022 Dec 5.
Hemoglobin increases leukocyte adhesion and initiates lung microvascular endothelial activation via Toll-like receptor 4 signaling.
Conger AK, Tomasek T, Riedmann KJ, Douglas JS, Berkey LE, Ware LB, Bastarache JA, Meegan JE.
Am J Physiol Cell Physiol. 2023 Mar 1;324(3):C665-C673. doi: 10.1152/ajpcell.00211.2022. Epub 2023 Jan 30.
Intestinal lymph-borne factors induce lung release of inflammatory mediators and expression of adhesion molecules after an intestinal ischemic insult.
Breithaupt-Faloppa AC, Vitoretti LB, Cavriani G, Lino-dos-Santos-Franco A, Sudo-Hayashi LS, Oliveira-Filho RM, Vargaftig BB, Tavares-de-Lima W.
J Surg Res. 2012 Jul;176(1):195-201. doi: 10.1016/j.jss.2011.06.074. Epub 2011 Jul 28.
Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.
Ortiz-Zapater E, Bagley DC, Hernandez VL, Roberts LB, Maguire TJA, Voss F, Mertins P, Kirchner M, Peset-Martin I, Woszczek G, Rosenblatt J, Gotthardt M, Santis G, Parsons M.
Nat Commun. 2022 Oct 27;13(1):6407. doi: 10.1038/s41467-022-33882-w.
The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development.
Röthe J, Kraft R, Ricken A, Kaczmarek I, Matz-Soja M, Winter K, Dietzsch AN, Buchold J, Ludwig MG, Liebscher I, Schöneberg T, Thor D.
Commun Biol. 2024 Jan 16;7(1):104. doi: 10.1038/s42003-024-05783-9.
Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling.
Almeida SFF, Santos L, Sampaio-Ribeiro G, Ferreira HRS, Lima N, Caetano R, Abreu M, Zuzarte M, Ribeiro AS, Paiva A, Martins-Marques T, Teixeira P, Almeida R, Casanova JM, Girão H, Abrunhosa AJ, Gomes CM.
J Exp Clin Cancer Res. 2023 Nov 30;42(1):328. doi: 10.1186/s13046-023-02886-9.
Alpha-1 antitrypsin inhibits fractalkine-mediated monocyte-lung endothelial cell interactions.
Mikosz A, Ni K, Gally F, Pratte KA, Winfree S, Lin Q, Echelman I, Wetmore B, Cao D, Justice MJ, Sandhaus RA, Maier L, Strange C, Bowler RP, Petrache I, Serban KA.
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 1;325(6):L711-L725. doi: 10.1152/ajplung.00023.2023. Epub 2023 Oct 10.
IFN-gamma Is Protective in Cytokine Release Syndrome-associated Extrapulmonary Acute Lung Injury.
Sun Y, Hu B, Stanley G, Harris ZM, Gautam S, Homer R, Koff JL, Rajagopalan G.
Am J Respir Cell Mol Biol. 2023 Jan;68(1):75-89. doi: 10.1165/rcmb.2022-0117OC.
Lipoteichoic acid inhibits lipopolysaccharide-induced adhesion molecule expression and IL-8 release in human lung microvascular endothelial cells.
Blease K, Chen Y, Hellewell PG, Burke-Gaffney A.
J Immunol. 1999 Dec 1;163(11):6139-47.
