Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.
Boteva L, Morris DL, Cortés-Hernández J, Martin J, Vyse TJ, Fernando MM.
Am J Hum Genet. 2012 Mar 9;90(3):445-56. doi: 10.1016/j.ajhg.2012.01.012. Epub 2012 Mar 1.
PMID:22387014
Complement C4-deficient mice have a high mortality rate during PTZ-induced epileptic seizures, which correlates with cognitive problems and the deficiency in the expression of Egr1 and other immediate early genes.
Veremeyko T, Jiang R, He M, Ponomarev ED.
Front Cell Neurosci. 2023 May 10;17:1170031. doi: 10.3389/fncel.2023.1170031. eCollection 2023.
PMID:37234916
Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.
Kotilainen H, Lokki ML, Paakkanen R, Seppänen M, Tukiainen P, Meri S, Poussa T, Eskola J, Valtonen V, Järvinen A.
PLoS One. 2014 Mar 17;9(3):e91450. doi: 10.1371/journal.pone.0091450. eCollection 2014.